Research Article, J Appl Bioinforma Comput Biol Vol: 5 Issue: 1
Anticarcinogenic Effects of Selected Alkaloids Identified from Cyperus Rotundus: An In Silico Perspective
| Lydia J1* and Sudarsanam D2 | |
| 1Department of Microbiology, Maharani’s Science College, Bangalore, India | |
| 2Department of Advanced Zoology, Biotechnology and Bioinformatics, Loyola College, Chennai, India | |
| Corresponding author : Lydia J Department of Microbiology, Research Associate: DBT-BIF, Maharani’s Science College, Bangalore, India Tel: +91 80 2334 9311 E-mail: lydia.jothi@gmail.com |
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| Received: February 02, 2016 Accepted: February 26, 2016 Published: February 29, 2016 | |
| Citation: Lydia J, Sudarsanam D (2016) Anticarcinogenic Effects of Selected Alkaloids Identified from Cyperus Rotundus: An In Silico Perspective. J Appl Bioinform Comput Biol 5:1. doi:10.4172/2329-9533.1000122 |
Abstract
Anticarcinogenic Effects of Selected Alkaloids Identified from Cyperus Rotundus: An In Silico Perspective
Cyperus rotundus Linn, commonly referred to as nut grass or purple nut sedge, is a perennial grass distributed widely in the warmer parts of the world. Various parts of the plant are being used as traditional remedies for diverse aliments. Five alkaloids identified from the ethanolic extract were modelled and docked with the emerging anticancer drug target, DNA polymerase β, which fill gaps during the repair of damaged DNA. The ADME properties of the alkaloids were also analysed and compared with that of Cytarabine. Two potential inhibitors of DNA polymerase β were identified, with ADME properties similar to that of cytarabine. It is therefore proposed that this compound, if isolated and purified, could be used for further in vivo or clinical studies. Three other alkaloids of which two were novel, presented exceptional ADME properties, but yielded lesser docking scores, suggesting that, a combination of the plants’ alkaloids would also be beneficial for anticancer therapy.
