Autoimmune Diseases And Rosai- Dorfman Disease Coexist More Commonly Than Expected

Lia NL^1*, Asad SD², Jafri SI³ and Harrison JS³

¹Department of Internal Medicine, University of Connecticut School of Medicine, Farmington, USA

²Department of Neurology, University of Connecticut School of Medicine, Farmington, USA

³Department of Medicine and the Carole and Ray Neag Cancer Center, University of Connecticut School of Medicine, Farmington, USA

*Corresponding Author : Nerea Lopetegui Lia
Department of Internal Medicine, University of Connecticut School of Medicine, Farmington, Connecticut, USA
E-mail: lopeteguilia@uchc.edu

Received: December 11, 2018; Accepted: January 07, 2019; Published: January 14, 2019

Citation: Lia NL, Asad SD, Jafri SI, Harrison JS (2019) Autoimmune Diseases and Rosai-Dorfman Disease Coexist More Commonly than Expected. J Blood Res Hematol Dis 3:1. doi: 10.4172/jbrhd.1000114

The educational objective herein is to describe 2 case reports in which patients were found to have an autoimmune disease concomitantly with a rare, benign histiocytic disorder known as Rosai-Dorfman disease (RDD). It is unclear if there is an underlying association between autoimmune disease and RDD, as the pathophysiology of RDD has not been well defined to date. Regardless, autoimmune diseases are relatively common in the general population; hence RDD should remain within the differential diagnosis when lymphadenopathy is seen. Lymphadenopathy, although most frequently seen bilaterally in the cervical region in RDD, may present anywhere. A biopsy with histologic confirmation is required to not only evaluate for malignancy in these cases but also necessary to diagnose RDD. Further basic scientific and clinical research is required to fully understand all the characteristics and optimal management of RDD disease. However, we have observed in these two cases presented, that if the autoimmune disease is well controlled, RDD can be an indolent disease.