Research Article, Analg Resusc Curr Res S Vol: 2 Issue: 0
Comparing Resuscitative Measures for Bupivacaine Toxicity Utilizing Lipid Emulsions in a swine model(Sus scrofa)
| Andrea Hudson1, Sarah Bolin2, Mark Bishop3, Randall Schmidt4, Arthur D Johnson5 and Joseph O’Sullivan5* |
| 1Landstuhl Regional Medical Center, Landstuhl, Germany |
| 2Madigan Army Medical Center, Tacoma, Washington, USA |
| 3Ireland Army Community Hospital, FT Knox, Kentucky, USA |
| 4Dwight D Eisenhower Army Medical Center, FT Gordon, Georgia, USA |
| 5Army Medical Department Center and School, San Antonio, Texas, USA |
| Corresponding author : Joseph O’Sullivan 3490 Forage Rd, Dunlap Hall, Ft Sam Houston, TX 78234 Tel: 210-295-4769 E-mail: joseph.c.osullivan.mil@mail.mil |
| Received: May 13, 2013 Accepted: July 01, 2013 Published: July 08, 2013 |
| Citation: Hudson A, Bolin S, Bishop M, Schmidt R, Johnson AD, et al. (2013) Comparing Resuscitative Measures for Bupivacaine Toxicity Utilizing Lipid Emulsions in a swine model (Sus scrofa). Analg Resusc: Curr Res S1. doi:10.4172/2324-903X.S1-006 |
Abstract
Comparing Resuscitative Measures for Bupivacaine Toxicity Utilizing Lipid Emulsions in a swine model(Sus scrofa)
A toxic dose of bupivacaine causes cardiac arrhythmias and ultimately asystole. Resuscitation is difficult and almost always unsuccessful. Until recently, cardiopulmonary bypass was the only effective treatment. Anecdotal evidence suggests that infusion of lipid emulsion may be an effective treatment. No studies have determined the optimal combination of lipid rescue and traditional Advanced Cardiac Life Support (ACLS) therapy for a toxic dose of bupivacaine. The purpose was to determine the optimal combination of lipid rescue and traditional ACLS therapy for treatment overdose of bupivacaine.
