Research Article, J Pharm Sci Emerg Drugs Vol: 2 Issue: 1
First Dose Combination Studies of Anti-Tuberculosis Drugs With Piperic Acid
| Gabriel Oliveira de Resende1, Bruno Almeida Cotrim1, Emerson Teixeira da Silva2, Maria Cristina Silva Lourenço2, Bruna Vitor de Almeida Rito1 and Marcus Vinícius Nora de Souza3* | |
| 1Instituto Federal de Educação Ciência e Tecnologia do Rio de Janeiro (IFRJ) - Unidade Rio de Janeiro. Rua Senador Furtado,121, Maracanã, 20270-021 - Rio de Janeiro-RJ, Brazil | |
| 2Fiocruz-Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos- Farmanguinhos. Rua Sizenando Nabuco, 100, Manguinhos, 21041-250 - Rio de Janeiro-RJ, Brazil | |
| 3Instituto de Pesquisas Clínica Evandro Chagas – IPEC – Av. Brasil, 4365 - Manguinhos Rio de Janeiro – RJ, Brazil | |
| Corresponding author : Marcus Vinícius Nora de Souza Instituto de Pesquisas Clínica Evandro Chagas – IPEC – Av. Brasil, 4365 - Manguinhos Rio de Janeiro – RJ, Brazil E-mail: marcos_souza@far.fiocruz.br |
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| Received: February 19, 2014 Accepted: October 06, 2014 Published: October 11, 2014 | |
| Citation: Resende GOD, Cotrim BA, Silva TD, Lourenço MCS, Rito BVDA, et al. (2014) First Dose Combination Studies of Anti-Tuberculosis Drugs With Piperic Acid. J Pharm Sci Emerg Drugs 2:1. doi:10.4172/2380-9477.1000103 |
Abstract
First Dose Combination Studies of Anti-Tuberculosis Drugs With Piperic Acid
The combinatorial effect of piperic acid with various anti-tuberculosis (anti-TB) drugs was evaluated in vitro against Mycobacterium tuberculosis. The present study has demonstrated for the first time that a combination of piperic acid with rifampicin imparts a synergic effect against M. tuberculosis.
