Identification of Protease Inhibitor- Caspase-6

Caspase-6 is a cysteine protease that plays important roles in axonal degeneration, programmed cell death, and development. The excess neuronal activity of Caspase-6 is associated with age-dependent cognitive impairment and Alzheimer disease neuropathology. The activation of the Caspase-6, aspartate-specific cysteinyl protease is proposed as an Huntington’s disease and early pathogenic event of Alzheimer disease (AD). Caspase-6 inhibitors could be useful against these neurodegenerative diseases but most of the Caspase-6 inhibitors is used  for the study  of  in vitro, show acute liver toxicity in humans.