Research Article, J Pharm Sci Emerg Drugs Vol: 7 Issue: 1
Preparation Optimization and Evaluation of Okra Mucilage Sodium Alginate Mucoadhesive Composite Beads
Meenakshi Bhatia, Priya Diman* and Prerna
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125001, Haryana, India
*Corresponding Author : Priya Dhiman
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125001, Haryana, India
E-mail: Priyadhiman062@gmail.com
Received: Febrauary 14, 2018 Accepted: March 28, 2019 Published: May 28, 2019
Citation: Bhatia M, Diman P, Prerna (2019) Preparation, Optimization and Evaluation of Okra Mucilage-Sodium Alginate Mucoadhesive Composite Beads. J Pharm Sci Emerg Drugs 7:1. doi: 10.4172/2380-9477.1000133
Abstract
The objective of the study is to prepared, optimize and evaluate metformin hydrochloride loaded OM-SA beads as mucoadhesive drug delivery system. The beads were prepared by ionic gelation method using calcium chloride as a cross linker. The prepared formulation was optimized by using 3-factor-3-level central composite design. The synthesized okra, alginate composite beads were characterized by fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy. The results revealed that okra mucilage/alginate, concentrations of calcium chloride and hardening time exerted significant effect on % entrapment, % release rate, % mucoadhesion, %swelling and % yield. Analysis of Variance (ANOVA) was applied on the % entrapment, % Rel24 and % mucoadhesion and %swelling of beads to study the fitting and significance of the model. Ex-vivo mucoadhesion time and in vitro drug release studies revealed that cumulative percent of drug released was found to be 100% over a time period of 24 hr. The prepared beads showed sustain release and used for the treatment of diabetesII.
