Review Article, J Spine Neurosurg S Vol: 0 Issue: 0
Role of IL-17 in Glioma Progression
| Prahlad Parajuli* and Sandeep Mittal | |
| Department of Neurosurgery, Wayne State University and Karmanos Cancer Institute, Detroit, USA | |
| Corresponding author : Prahlad Parajuli Department of Neurosurgery, 550 E. Canfield, Lande Bldg #460, Wayne State University and Karmanos Cancer Institute, Detroit, MI 48201, USA Tel: (313) 577-6377 E-mail: pparajuli@med.wayne.edu |
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| Received: June 02, 2013 Accepted: October 14, 2013 Published: October 18, 2013 | |
| Citation: Parajuli P, Mittal M (2013) Role of IL-17 in Glioma Progression. J Spine Neurosurg S1. doi:10.4172/2325-9701.S1-004 |
Abstract
Role of IL-17 in Glioma Progression
There is increasing evidence in the literature pointing to an important role of inflammation during initiation and progression of cancer. Glioblastoma is the most common malignant primary brain tumor with approximately 23,000 newly-diagnosed cases each year in the United States, and has a dismal median survival of only 15 months. Although the blood-brain barrier maintains an immuneprivileged status of the brain under steady state, intracranial tumors including gliomas are invariably infiltrated with various types of immune cells.
