Specific Characteristics of the Esophageal Carcinosarcoma at Multi-Omics Levels: A Rare Case Report

Esophageal carcinosarcoma is a rare cancer type, which accounts for approximately 3% in esophageal neoplasms with low 5-year overall survival. Carcinosarcoma is biphasic in nature which consists of both carcinomatous and sarcomatous elements. Of these sarcomatous components, fibrosarcoma is the most common type and others include leiomyosarcoma, rhabdomyosarcoma, chondrosarcoma, osteosarcoma, liposarcoma, chondrosarcoma and so on. Since the first description of this neoplasm by Chapman in 1877, esophageal carcinosarcoma cases have been reported, but its pathogenesis is still unclear. Here, we report a case with complete follow-up data and integrated high-throughput data, which could contribute to elucidating the pathophysiological mechanisms of diseases accurately and provide novel therapeutic strategies to the clinical research. To the best of our knowledge, this is the first reported case to characterize its characteristics at multi-omics levels.