Research Progress on the Alleviation of Alcoholic Liver Injury based on Bibliometric Analysis of Medicinal and FoodHomologous Substances

Objective: This paper analyze the research status and hot contents in the field related to alleviating alcoholic liver injury by medicinal and food homologous substances, and provide ideas for researchers to further in-depth study their alleviation effects on alcoholic liver injury. Methods: By using the bibliometric method, the CNKI, WOS and PubMed databases as the literatures source, the distribution of literatures in the field of alleviating alcoholic liver injury from the establishment of the library to 2022 is searched and analyzed. Results: A total of 418 Chinese and English literature and 276 patents on alleviating alcoholic liver injury with drugs and food homologous substances is obtained. Results show that domestic research in this field started late, but its development speed is fast, and the number of domestic publications and patents are higher than that of foreign countries. The trends in the number of publications and patents show exponential and linear increase, respectively. The research hotspots mainly focus on the effect mechanism of Kudzu, Hovenia dulcis Thunb, Goji berry and other medicinal and food homologous substances in alleviating alcoholic liver injury. Conclusion: By analyzing the research status of the literature and patent, the pathogenesis of alcoholic liver injury is systematically summary, mainly relate to the ethanol metabolism, oxidative stress, immune inflammatory response and impaired intestinal barrier and dysbacteriosis. The influencing mechanism of medicinal and food homologous substances in alleviating alcoholic liver injury is mainly related to anti-lipid peroxidation, oxidative stress response, anti-inflammatory effect, scavenging of free radicals, and regulation of intestinal flora. In the future, this field will be further studied in the mechanism by network pharmacology, histological techniques and other methods.